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"If a man says 'no' to you with a lot of irritability, I still wouldn't take it personally or feel rejected, because it's very likely he's suffering some depression -- and again, it's not you," says Foley.
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The type of medical specialist who treats ED will depend on the cause of the problem. Based on your family's medical history as well as your own medical history and current health, your doctor may treat you with oral medications such as Viagra or similar drugs. If this fails, he or she may refer you to a urologist or psychologist.
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Men who present with diminished libido and ED may be found to have low serum testosterone levels. Hormone replacement may be of benefit to those with severe hypogonadism and possibly as adjunctive therapy when other treatments are unsuccessful by themselves. Libido and an overall sense of well-being are likely to improve when serum testosterone levels are restored to the reference range.
Normal penile erection is dependent on the integrity of the endothelium. Endothelial-derived NO plays an important role in the physiological mechanism of erection. Alteration in the concentration of NO, due to damage to endothelium or to increased destruction, appears to be the most important causes for ED, especially in the presence of vascular disease. In vitro studies showed that increased production of reactive oxygen species is associated with decreased normal erectile response, primarily because of reduced NO concentrations. Increased production of reactive oxygen species in diseases such as diabetes and hypertension might be an important cause of an increased risk of ED. Novel strategies and interventions are needed to prevent and treat endothelial damage.
Oral sildenafil appears to be safe in the treatment of erectile dysfunction in the real world. It is accepted widely by our patients as first line treatment and is successful in 91% of our patients. At the end of the study period 80% of the patients were willing to continue with sildenafil therapy. In our part of the United Kingdom, there is a large expectation for ED to be treated in the NHS. Of those men eligible for treatment of their ED in the NHS, 30% qualify under the clinical categories and 18% under the 'distress' category. This has implications on the local prescribing policies and resources. Under the current guidelines, only 55% of men with one or more cardiovascular risk factors qualify for treatment in the NHS. The majority of men presenting with ED could be managed in primary care.
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Results Two hundred fifty-two patients (94%) completed the study (131/136 in the sildenafil group, 121/132 in the placebo group). By intention-to-treat analysis, at 12 weeks, 74 (56%) of 131 patients in the sildenafil group reported improved erections compared with 13 (10%) of 127 patients in the placebo group (P<.001). The proportion of men with at least 1 successful attempt at sexual intercourse was 61% (71/117) for the sildenafil group vs 22% (25/114) for the placebo group (P<.001). Adverse events related to treatment were reported for 22 (16%) of 136 patients taking sildenafil and 1 (1%) of 132 patients receiving placebo. The most common adverse events were headache (11% sildenafil, 2% placebo), dyspepsia (9% sildenafil, 0% placebo), and respiratory tract disorder (6% sildenafil, 2% placebo), predominantly sinus congestion or drainage. The incidence of cardiovascular adverse events was comparable for both groups (3% sildenafil, 5% placebo).
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What the commercials don't show you: The painful distress a woman can experience when her man suffers with erectile dysfunction (ED).
Figure 5. Sildenafil down-regulates IL-4R expression on CD11b+ cells. CD4+, CD8+, CD11b+, or CD11c+ cells were magnetically purified from spleens of C26GM-bearing mice challenged 9 d earlier. CD4+ or CD8+ T cells were stimulated with ConA for 3 d, with or without 50 µg/ml sildenafil. (A) Purified cells were cultured separately for 2 d with or without sildenafil, harvested, and used to determine cGMP levels, as described in Materials and methods. (B) T cell proliferation was determined by [3H]thymidine incorporation. (C) CD11c+ cells were analyzed for B7.2 and MHC class II expression. (D) CD11b+ cells were analyzed for IL-4R expression by flow cytometry. The t test p-value is reported. Error bar values are shown. MFI, multiplicity of infection.
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Erectile Dysfunction: A Harbinger of Heart Trouble
Nocturnal penile tumescence (NPT)–It is normal for a man to have five to six erections during sleep, especially during rapid eye movement (REM). These erections occur about every 90 minutes and last for about 30 minutes. Their absence may indicate a problem with nerve function or blood supply in the penis. There are two methods for measuring changes in penile rigidity and circumference during nocturnal erection: snap gauge and strain gauge.
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A useful and simple way to distinguish between physiological and psychological impotence is to determine whether the patient ever has an erection. If never, the problem is likely to be physiological; if sometimes (however rarely), it is more likely to be psychological.
Digital Subtraction Angiography
An erection occurs as a hydraulic effect due to blood entering and being retained in sponge-like bodies within the penis. The process is most often initiated as a result of sexual arousal, when signals are transmitted from the brain to nerves in the pelvis. Erectile dysfunction is indicated when an erection is consistently difficult or impossible to produce, despite arousal. There are various and often multiple underlying causes, some of which are treatable medical conditions. The most important organic causes are cardiovascular disease and diabetes, neurological problems (for example, trauma from prostatectomy surgery), hormonal insufficiencies (hypogonadism) and drug side effects. It is important to realize that erectile dysfunction can signal underlying risk for cardiovascular disease.
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The new cream consists of nanoparticles that can carry drugs or other substances, such as nitric oxide, and deliver them in a controlled and sustained manner, according to the researchers, who are from Albert Einstein College of Medicine at Yeshiva University in New York City. Nitric oxide is the signaling molecule that dilates blood vessels responsible for creating an erection.
Missed Signals
"IUD" stands for "intrauterine device." An IUD is put in a woman's uterus by her doctor. It's made of flexible plastic. It isn't known exactly how IUDs prevent pregnancy. They seem to stop sperm from reaching the egg or prevent the egg from attaching to the uterus.
Medications: Many common medicines produce erectile dysfunction as a side effect. Medicines that can cause erectile dysfunction include many used to treat high blood pressure, antihistamines, antidepressants, tranquilizers, and appetite suppressants. Examples of common medicines that can cause erectile dysfunction include beta-blockers such as propranolol (Inderal), hydrochlorothiazide, digoxin (Lanoxin), amitriptyline (Elavil), famotidine (Pepcid), cimetidine (Tagamet), metoclopramide (Reglan), indomethacin (Indocin), lithium (Eskalith; Lithobid), verapamil (Calan, Verelan, Isoptin), phenytoin (Dilantin), and gemfibrozil (Lopid). For more, please visit the Medications Index.
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